{"id":32920,"date":"2020-11-18T16:21:04","date_gmt":"2020-11-18T15:21:04","guid":{"rendered":"https:\/\/www.micropticsl.com\/is-casa-really-required-blog\/"},"modified":"2026-06-29T14:36:57","modified_gmt":"2026-06-29T12:36:57","slug":"is-casa-really-required-blog","status":"publish","type":"post","link":"https:\/\/www.micropticsl.com\/es\/is-casa-really-required-blog\/","title":{"rendered":"Is CASA really required?"},"content":{"rendered":"
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Is CASA really required? Views from the past, the present and the future<\/h2>\n

The big questions are: Does CASA measure sperm parameters such as motility, morphology, vitality etc. quantitatively, accurately and to what extent does it enhance clinical spermatology for human and animals and wildlife? Does it provide answers not only on sperm quality but sperm functionality and fertilizing ability? To answer these crucial questions and its relevance, it is important to follow the historical development of CASA and just how difficult it was to get where we are today.<\/p><\/blockquote>\n

Early development in 1980\u2019s and early 1990\u2019s<\/strong><\/p>\n

Computer Aided Sperm Analysis (CASA) has been around for almost four decades. In 1985 CellSoft was the first major CASA system and only in the late 1980\u2019s the first Hamilton Thorne system and CellTrack of Motion Analysis emerged. These systems for the first time provided at 30fps quantification of sperm motility and sperm concentration. While this presented major breakthroughs for quantifying sperm motility, they were largely black boxes with little true verification and scepticism. \u00a0In 1992 The Sperm Motility Quantifier was developed in South Africa as a joint effort of the CSIR and the University of the Western Cape (Fig. 1). While it was a simpler system than the commercialized and well-established systems mentioned above, it provided verification of sperm tracks (replay) and was the first to operate at 50fps (Fig. 2). In general, all these CASA systems were not really trusted in the clinical setting despite many research papers providing new and useful information.<\/p>\n\n\t\t